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PD CEN/TS 17273:2018 Nanotechnologies. Guidance on detection and identification of nano-objects in complex matrices, 2019
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- Introduction
- 1 Scope
- 2 Normative references
- 3 Terms and definitions
- 4 Symbols and abbreviations
- 5 Possible tasks and measuring techniques [Go to Page]
- 5.1 Examples for detection and identification tasks in complex matrices
- 5.2 Overview of measurement techniques
- 6 Guidance on sample preparation, particle detection and identification of nano-objects in complex matrices [Go to Page]
- 6.1 Approach for “Detection and Identification of a relevant population of nano-objects based on a priori knowledge” (guidance chart)
- 6.2 Information about the targeted nano-objects
- 6.3 Information about the sample matrix
- 6.4 Sample Preparation Process Quality assessment [Go to Page]
- 6.4.1 Suspension, dispersion with recovery evaluation and property assessment
- 6.4.2 Initial size distribution measurement and mass concentration measurement of all isolated nano-objects
- 6.5 Measurement of the targeted nano-objects and evaluation
- 7 Selected measuring techniques for the detection and identification of nano-objects [Go to Page]
- 7.1 Field-Flow-Fractionation (FFF) technique [Go to Page]
- 7.1.1 General
- 7.1.2 Fractionation principle and theory — Fractionation principle
- 7.1.3 Detection principle
- 7.1.4 Performance
- 7.1.5 Sample preparation
- 7.1.6 Analysis report and interpretation of results
- 7.2 Electron Microscopy (EM) technique [Go to Page]
- 7.2.1 General
- 7.2.2 Measuring principle of Electron Microscopy [Go to Page]
- 7.2.2.1 General
- 7.2.2.2 Transmission Electron Microscopy (TEM)
- 7.2.2.3 Scanning Electron Microscopy including Scanning Transmission Electron Microscopy
- 7.2.3 Performance of Electron Microscopy
- 7.2.4 Specimen preparation for Electron Microscopy
- 7.2.5 Interpretation of Electron Microscopy results
- 7.3 Single particle Inductively Coupled Plasma Mass Spetrometry (spICP-MS) [Go to Page]
- 7.3.1 Measuring principle
- 7.3.2 Performance
- 7.3.3 Sample preparation
- 7.3.4 Interpretation of results
- 8 List of reporting requirements on sample preparation, detection and identification of nano-objects in complex matrixes [Go to Page]
- 8.1 General reporting
- 8.2 Sample preparation reporting, explained in Clause 6
- 8.3 Measurement reporting, explained in Clause 7
- Annex A (informative)Indicative ranges of size and concentration of selected measuring techniques
- Annex B (normative)Theory of F4 separations, precautions when separating broad particle size distributions and sample preparation [Go to Page]
- B.1 Theory of F4 separations
- B.2 F4 calibration using F4 theory or external references
- B.3 Approaches to prepare complex samples for FFF
- Annex C (informative)Example: Analysis of the release of particles from the coating of silver-coloured pearls by a combination of descriptive TEM analysis, electron diffraction, analytical TEM and quantitative TEM [Go to Page]
- C.1 Approach and methodology
- C.2 Results
- Annex D (informative)Example: Single particle ICP-MS for sizing and quantitative determination of nano-silver in chicken meat [Go to Page]
- D.1 Introduction
- D.2 Method Description [Go to Page]
- D.2.1 Materials and Methods
- D.2.2 Sample Preparation
- D.2.3 Instrumental Analysis
- D.2.4 Data Processing
- D.3 Results and Discussion [Go to Page]
- D.3.1 Sample enzymatic digestion: soft conditions to preserve particle characteristics
- D.3.2 Study Design and Results of Validation
- D.3.3 Repeatability, reproducibility, and trueness
- D.3.4 Linearity and LOD/LOQ, Robustness, specificity/selectivity
- Annex E (informative)Overview of alternative detection methods [Go to Page]
- E.1 General
- E.2 Particle Tracking Analysis (PTA)
- E.3 Tracer methods by using stable isotopic labelled nano-objects
- E.4 HyperSpectral Imaging System (HSIS) by scattering in a dark-field background
- E.5 Size evaluation by UV-vis spectroscopy
- E.6 Sizing nano-objects in liquids using differential mobility analysing system (DMAS)
- E.7 Laser-Induced Breakdown Detection (LIBD)
- E.8 Hydrodynamic chromatography ICP-MS (HDC-ICP-MS) and size exclusion ICP-MS (SEC-ICP-MS) [Go to Page]