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  • BSI
    BS EN ISO 20046:2021 Radiological protection. Performance criteria for laboratories using Fluorescence In Situ Hybridization (FISH) translocation assay for assessment of exposure to ionizing radiation
    Edition: 2021
    $473.45
    / user per year

Description of BS EN ISO 20046:2021 2021

The purpose of this document is to provide criteria for quality assurance (QA), quality control (QC) and evaluation of the performance of biological dosimetry by cytogenetic service laboratories.

This document addresses:

  1. the responsibilities of both the customer and the laboratory;

  2. the confidentiality of personal information, for the customer and the laboratory;

  3. the laboratory safety requirements;

  4. sample processing; culturing, staining and scoring, including the criteria for scoring for translocation analysis by FISH;

  5. the calibration sources and calibration dose ranges useful for establishing the reference dose‑response curves that contribute to the dose estimation from chromosome aberration frequency and the detection limit;

  6. the scoring procedure for translocations stained by FISH used for evaluation of exposure;

  7. the criteria for converting a measured aberration frequency into an estimate of absorbed dose (also appears as “dose”);

  8. the reporting of results;

  9. the QA and QC;

  10. Annexes A to F containing sample instructions for the customer, sample questionnaire, sample datasheet for recording aberrations, sample of report and fitting of the low dose-response curve by the method of maximum likelihood and calculating the uncertainty of dose estimate.



Standard NumberBS EN ISO 20046:2021
TitleRadiological protection. Performance criteria for laboratories using Fluorescence In Situ Hybridization (FISH) translocation assay for assessment of exposure to ionizing radiation
StatusDefinitive
Publication Date2021-02-23
Identical National Standard OfISO 20046:2019, EN ISO 20046:2021
CorrectsBS ISO 20046:2019
DescriptorsRadiation measurement, Radionuclides, Radioactive materials, Neutrons, Detectors, Performance, Spectroscopy, Identification methods, Radiation protection, Manually-operated devices, Portable, Dosimeters, Photons, Measuring instruments
ICS13.280 Radiation protection
CommitteeNCE/2
ISBN978 0 539 14652 3
PublisherBSI
Pages50

About BSI

BSI Group, also known as the British Standards Institution is the national standards body of the United Kingdom. BSI produces technical standards on a wide range of products and services and also supplies certification and standards-related services to businesses.
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