ASTM E1619-95(1999)
Historical Standard: ASTM E1619-95(1999) Standard Test Method for Chronic Oral Toxicity Study in Rats
SUPERSEDED (see Active link, below)
ASTM E1619
1. Scope
1.1 This test method covers a long-term study to determine the effects of a substance in a mammalian species such as the rat following prolonged and repeated oral exposure. Under the conditions of the chronic toxicity test, effects that require a long latency period or that are cumulative should become manifest.
1.2 This test method assumes that the user is knowledgeable in mammalian toxicology and related pertinent areas, and relies heavily on the judgment of the evaluator.
1.3 The values stated in SI units are to be regarded as the standard. The inch-pound units given in parentheses are for information only.
1.4 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use. For specific hazard statements, see Section 6.
2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.
ASTM Standards
E609 Terminology Relating to Pesticides
E943 Terminology Relating to Biological Effects and Environmental Fate
Federal Standards
Title40, CFR, Environmental Protection Agency, Part 798, Health Effects Testing Guidelines, Subpart D, Chronic Exposure, Chronic ToxicityKeywords
blood chemistry; chronic toxicity; feed efficiency; gavage; hematology; LD 50 ; necropsy; oral; pesticide; rat; toxicity; urinalysis: Blood chemistry; Chronic toxicity tests; Feed efficiency; Gavage; Hematology; LD50 test; Necropsy; Pesticides; Rats; Toxicity/toxicology; Urinalysis
ICS Code
ICS Number Code 11.100 (Laboratory medicine)
DOI: 10.1520/E1619-95R99
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